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diagnosis differential hematology causes management algorithm clinical nephrology dermatology hepatology oncology liver microscopy anemia pathology renal rheumatology signs smear symptoms
Sickle cell anemia and Howell Jolly bodies (nuclear remnants). - Dr. Abubaker Elshaikh @ElshaikhMD #SickleCell #HowellJolly #Body #Bodies
anemia and Howell Jolly ... #SickleCell #HowellJolly
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... glomerular hematuria (RBC ... or dysmorphic RBCs ... Nephritic #Nephrotic #Syndrome
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
photo are a Howell-Jolly ... TargetCells #Target #HowellJolly
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Red Blood Cell (RBC ... cell, Other RBC ... bodies, Howell-Jolly ... bodies #RBC
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... Associations • Howell Jolly ... Sickle cell, MDS #RBC
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... Nephrotic yndrome—podocyte ... Nephritic #Nephrotic #Syndromes
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... Drug-associated, PCH, Evans Syndrome ... 3) Internal (RBC ... Smear ↑ abnormal RBCs
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal Syndrome ... Pulmonary Renal Syndromes ... Infection, Alport Syndrome ... Investigations • Labs: CBC ... proteinuria, dysmorphic RBCs
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... urine sediment - WBC ... /RBC casts
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... coagulopathy (DIC) #RBC
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