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diagnosis classification hematology hemophagocytic lymphohistiocytosis rheumatology boop casts checklist clinical crisis criticalcare cxr dermatology devices distribution endocrinology equipment fatigue frames
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... , Biological + Bone ... /ml, ↑ LDH • Bone ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management
Priapism Secondary Causes: Medications- intracavernosal injections, anticoagulants, PDE5 inhibitors, alpha blockers, methylphenidate, cocaine Any hyperviscosity syndrome (SCD, leukemia,
Secondary Causes ... Some other random ones ... Priapism #Diagnosis #Management ... #Urology #Differential
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
Chronic diarrhea / IBD ... Pancreatitis - Hungry bones ... Hypomagnesemia #Differential ... Classification #Causes
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Short Stature - Differential ... Diagnosis Algorithm ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Algorithm • 40- ... Receptor (sTfR) to differentiate ... /other causes • ... #Algorithm #diagnosis ... #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammation of the bones ... Rule out other causes ... -1 inhibitors, IL ... inhibitors, and IL ... Rheumatology #diagnosis #management
Notice that there are multiple densities in both lungs. The larger ones are ill-defined and maybe there
The larger ones ... are ill-defined ... possibility of multiple ill-defined ... masses. ... dealing with the differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... Lymphoma (90-95% of cases ... Immunohistochemical studies (to differentiate ... anymore • Routine bone ... hematology #oncology #management
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... Vascular Causes ... PBC, PSC, IgG4, HLH ... hemolysis) • ALP: Bone
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome caused ... ., IFN-γ, TNF, IL ... Hemophagocytosis in bone ... Approach • Initial management
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