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diagnosis differential hepatology management alkaline alp hemophagocytic hlh lymphohistiocytosis phosphatase rheumatology syndrome cirrhosis dermatology elevation endocrinology hemeonc hepatitis hepatopulmonary hps
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... Generally affects long bones ... BrighamChiefs #Bone ... #hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... - Bone symptoms ... #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... inflammation of the bones ... • Bone and joint ... Rule out other causes ... osteoarticular and skin disease
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... • Cushing's Disease ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... , Biological + Bone ... /ml, ↑ LDH • Bone ... • Autoimmune diseases ... Adult-onset Still disease
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... hemolysis) • ALP: Bone ... differential #diagnosis #algorithm ... #hepatology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
• Domestic and wild ... • Chronic lung disease ... status NTM Cause ... Hematologic malignancy ... ) - Bone Marrow
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
vessels + absent tone ... arteriovenous shunting causes ... the lower lung zones ... MELD) • In one ... cirrhosis #diagnosis #hepatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... ▪ Autoimmune diseases ... ., IFN-γ, TNF, IL ... Hemophagocytosis in bone ... Diagnosis #Management #Hematology
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