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diagnosis treatment hematology syndrome dermatology differential hemophagocytic hlh lymphohistiocytosis orthopedics pathophysiology rheumatology amyloid amyloidosis ascorbicacid atopic atopy casts cell chagas
Paget's Disease of Bone • Characterized by an ↑ rate of bone turnover with both excessive
by an ↑ rate of bone ... • Caused by ( ... more (polystotic) bones ... pelvis, and long bones ... #management #treatment
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... MSK • Deformed bones ... Lytic lesions make bones ... Nerve Palsies • Disordered ... of middle ear bones
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
of bone, joint, ... inflammation of the bones ... Rule out other causes ... osteoarticular and skin disease ... Rheumatology #diagnosis #management
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm Tumours - See Bone Lesions Scheme Paget's Disease -
Differential Diagnosis Algorithm ... Tumours - See Bone ... • Bone Marrow ... Disorder • Endocrinopathy ... #Orthopedics #Causes
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... • Cushing's Disease ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... , Biological + Bone ... /ml, ↑ LDH • Bone ... • Autoimmune diseases ... Lymphohistiocytosis #diagnosis #management
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
particular affinity for bone ... areas include the bones ... pituitary gland • Bone ... ribs, and long bones ... Liver, Spleen, Bone
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... Mucous membranes • Bone ... failure to thrive • Ill ... , or any other cause ... Nutrition #Diagnosis #Management
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
Diagnosis and Management ... caused by the protozoan ... Vector-borne (most ... asymptomatic or mild ... Cardiomyopathy: Conduction disorders
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... • Autoimmune disorders ... anymore • Routine bone ... number of sites of disease ... hematology #oncology #management
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