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diagnosis differential management hemophagocytic lymphohistiocytosis rheumatology dermatology dizziness dizzy endocrinology hematology hemeonc hepatitis hepatology injury liver neurology pediatrics sapho shortstature
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... , Biological + Bone ... /ml, ↑ LDH • Bone ... • Autoimmune diseases ... Adult-onset Still disease
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm True Vertigo - Illusion of Rotary Movement Peripheral Vestibular
Differential Diagnosis Algorithm ... • Meniere's Disease ... oscillopsia) • Otitis ... Media • Temporal Bone ... #Causes
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... inflammation of the bones ... • Bone and joint ... Rule out other causes ... osteoarticular and skin disease
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... • Cushing's Disease ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... PBC, PSC, IgG4, HLH ... hemolysis) • ALP: Bone ... differential #diagnosis #algorithm
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... ▪ Autoimmune diseases ... ., IFN-γ, TNF, IL ... Hemophagocytosis in bone ... Elevated soluble IL
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