27 results
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
disease (hematuria, proteinuria ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... staining on IF • No EM ... #Diagnosis #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... - Differential ... Algorithm Persistent Proteinuria ... proliferative • Anti-GBM ... #Nephrology #Differential
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
syndrome—due to GBM ... Proteinuria often ... Massive proteinuria ... Classification #Proteinuria ... #Nephrology #Diagnosis
Algorithm and Differential Diagnosis of Macroscopic Hematuria
Important Historical Elements:
- Painless: suggests malignancy
- Painful: suggests calculi/infection
- Urinalysis:
Algorithm and Differential ... RBC/WBC casts, proteinuria ... prostatic) #Diagnosis #EM ... #Macroscopic #Differential
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Glomerulonephritis - Differential ... Strauss) Anti-GBM ... Glomerulonephritis #differential ... #diagnosis #nephrology
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
• Breaks in GBM ... Glomerular #Diseases #differential ... spectrum #diagnosis #nephrology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Approach to the differential ... overt glomerular proteinuria ... Cytomegalovirus; GBM ... #Algorithm #differential ... nephrotic #syndrome #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
of Hematuria - Differential ... nephropathy • Thin GBM ... ) • Anti-GBM ... nephrotic range) proteinuria ... #Hematuria #Differential
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... • Urinalysis (proteinuria ... anti-ANCA ab, anti-GBM ... Renal #Syndrome #differential ... #diagnosis #nephrology
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
GBM, Glomerular ... Kidney #Injury #Differential ... Causes #Sites #Nephrology