29 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... Differential Diagnosis ... Cirrhosis • Chronic ... Viral Hepatitis ... #hepatology #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... (DILI) Viral Hepatitis ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology ... #diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... or symptoms of ... gastroenterology #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... B - Diagnosis and ... Management Algorithm ... Chronic Hepatitis ... #Hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
- Differential Diagnosis ... Chronic liver disease ... hepatitis) - 80% ... Fitz-Hugh-Curtis syndrome ... #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Nonalcoholic fatty liver ... heart failure (chronic ... disease (Budd-Chiari syndrome ... 14 percent) #Diagnosis ... #Differential #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... : Viral Hepatitis ... #Pregnancy #hepatology ... #management #pathophysiology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... - Symptoms of ... chronic inflammation ... (eg Viral) Management ... #Management #Hepatology