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diagnosis hematology management algorithm anticoagulation cardiology cancer endocarditis oncology pharmacology anticoagulant apixaban cardiomyopathy coagulation comparison dabigatran decisionaid deficiencies deficiency differential
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis. Currently, edoxaban and rivaroxaban are the only
anticoagulants (DOACs ... filtration rate; DOAC ... anticoagulant; LMWH ... body mass index; VTE ... #DOAC #VTE #Malignancy
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 Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
algorithm for VTE ... in Malignancy ... risk of recurrent VTE ... DOAC, direct oral ... #DOAC #VTE #Malignancy
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
the mainstay of VTE ... . heparin, LMWH, ... anticoagulant (e.g ... #UFH #DOAC #Dabigatran ... #Fondaparinux #NOAC
Choice of anticoagulant for treatment of pulmonary embolism • Malignancy - LMWH • To avoid parenteral
pulmonary embolism • Malignancy ... - LMWH • To avoid ... coagulopathy - LMWH ... • Pregnancy - LMWH ... #decisionaid #vte
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... Medications - Heparin, LMWH ... , warfarin, DOACs ... (e.g. direct factor ... most common) - Malignancy
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
thromboembolism (VTE ... • Provoked (e.g ... trauma, active malignancy ... an established malignancy ... - Recurrent VTE
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
cardiomyopathy (e.g ... Avoid Warfarin and DOAC ... hemodynamics (e.g ... LVEF recovery (e.g ... Serial TTE and close
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Non-Infectious (NTBE): • Malignancy ... cultures • 2D Echo TTE ... • TTE nondiagnostic ... ↑ ESR, CRP • EKG
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Non-Infectious (NTBE): • Malignancy ... cultures • 2D Echo TTE ... ○ TTE nondiagnostic ... ↑ ESR, CRP • EKG
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