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diagnosis differential management rheumatology druginduced hypokalemia nephrology sle adrenal antiphospholipid apls clinicopathology comparison dil endocrinology erythematosus evaluation hematology hypercoagulable hypomagnesemia
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... • Immunologic Workup ... in >90% - Low ... Positive in 60-80% of cases ... sle #comparison #table
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
Familial renal Mg wasting ... Differential #Diagnosis #Low ... #Magnesium #Table ... #Classification ... #Causes #Workup
Hypokalemia - Differential Diagnosis Poor Intake - Starvation - Anorexia GI Losses - Vomiting / NG
type 4) - Salt wasting ... Differential #Diagnosis #Low ... #Potassium #Table ... #Classification ... #Causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... versus DIL • Laboratory ... • Immunologic Workup ... Positive in 60-80% of cases ... 60-80% - Low
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
time you have a case ... normal volume-based algorithm ... can be high or low ... Cerebral Salt Wasting ... differential #diagnosis #table
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
aldosterone - Low ... in cases in which ... Insufficiency #Evaluation #laboratory ... #diagnosis #testing ... endocrinology #workup
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
cases, drug-dependent ... calcium-b) • Laboratory ... • Immunologic Workup ... in >90% - Low ... Discontinuation of causal
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup ... Algorithm INDICATIONS ... maternal chromosomal causes ... : • Lupus Anticoagulant ... #Algorithm #diagnosis
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
should use this algorithm ... risk of smallpox –low ... specimens from low ... See table below ... all HIGH RISK CASES
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
Pragmatic diagnostic algorithm ... urine Na/Cl > 1.6, low ... confirmed via genetic testing ... continued in most cases ... dependent upon local laboratory
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