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management pharmacology poisoning amiodarone anemia anthracycline aplastic aspirin bonytumor carbon cardiology cardiotoxicity checkpointinhibitor chemotherapy clozapine coronavirus covid19 encephalopathy features ferrous
Osteosarcoma Most common primary malignant bone tumor in children Most Common Sites of Involvement: 1. Distal femur
frequently begins after injury ... • Systemic symptoms ... #Osteosarcoma #Diagnosis ... #Features #Oncology ... #Peds #Pediatrics
Carbon Monoxide Poisoning Symptoms are non-specific: - Headache 90% - Nausea/vomiting 50% - Vertigo 50% - Altered
Monoxide Poisoning Symptoms ... affected (inc pets ... Outdoors improves symptoms ... Treatment: 100% ... Monoxide #Poisoning #Toxicology
Acute Iron Poisoning There are five classically described phases of toxicity: Gastrointestinal phase (~6 hours post-ingestion) -
described phases of toxicity ... caustic mucosal injury ... post-ingestion) - Symptom ... caustic bowel injury ... #Toxicology #Diagnosis
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
Salicylate Toxicity ... - Diagnosis and ... ingestion/exposure Symptoms ... #Toxicology #diagnosis ... #management #Treatment
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
anaerobic metabolism Diagnosis ... and acute kidney injury ... also includes symptoms ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis
Reported Mechanisms and Toxicity of Investigational Treatments for SARS-COV-2 Chloroquine and Hydroxychloroquine • Mechanisms: Interference with ligand
Mechanisms and Toxicity ... Investigational Treatments ... hearing loss, GI symptoms ... acidosis, renal injury ... #Toxicology #Medications
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Induced Muscle Toxicity ... Direct muscle injury ... Risk of muscle injury ... Atorvastatin Diagnosis ... #myopathy #diagnosis
Immune Checkpoint Inhibitor Toxicity Main Toxicities: Colitis, Pneumonitis, Skin adverse events, Endocrine dysfunction, Hepatitis, Myocarditis,
Checkpoint Inhibitor Toxicity ... Incidence, Symptoms ... Complications and Treatment ... SideEffects #Table #Diagnosis ... #Pharmacology #Oncology
Clozapine Toxicology Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... effect on negative symptoms ... #Clozapine #Toxicology ... #Toxicity #Diagnosis
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
cytotoxic lung injury ... starting amiodarone treatment ... gradually with symptoms ... Improvement in symptoms ... #management #Toxicology
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