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diagnosis management apml differentiation hemeonc hemophagocytic hlh leukostasis lymphohistiocytosis lysis oncology tls tumor
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... , AKI, acute limb ... WBC >100k, + lab signs ... diagnosis #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
or triggers) is crucial ... Presentation • Common Signs ... and Symptoms: ... Pathophysiology ... therapies: JAK inhibitors
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