7 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... immunofluorescence Immune ... With associated pulmonary ... Goodpasture's) Pauci-immune ... diagnosis #algorithm #rheumatology
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology
Risk factors:
 - Low CD4 count
 - Disseminated OI
 -
Immune Reconstitution ... Syndrome (IRIS) - Pathophysiology ... factors: - Low CD4 ... Syndrome #IRIS #Pathophysiology ... #AIDS
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... other cause of ARDS ... transfusion • Pathophysiology ... , and CXR with pulmonary ... Transfusion #Reactions #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... Others: Cellular immune ... treatment #summary #rheumatology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Immune Reconstitution ... treatment of HIV/AIDS ... be present: • AIDS ... Lymphadenitis, pulmonary ... lymphadenitis, pulmonary
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... Necrotizing, pauci-immune ... respiratory tracts Immune ... Lab Tests: • CBC ... differential #diagnosis #rheumatology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
host): • Chronic pulmonary ... symptoms • Rheumatologic ... Rhinocerebral 2) Pulmonary ... yeast • At risk: AIDS ... Aspergillosis Pathophysiology