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diagnosis management neurology syndrome causes hematology algorithm infectiousdiseases inflammatory oncology rheumatology syndromes aids classification idsa immunology infections opportunistic pharmacology pulmonary
Cellular and humoral immune responses of the adaptive immune system. Activated T cells accomplish cellular immune
Cellular and humoral immune ... of the adaptive immune ... associated with CD4 ... or CD8, depending ... ImmuneResponses #immunology #pathophysiology
Eosinophils (Eos) and hypereosinophilia (HE) Caused by eosinophilopoietic cytokines Common causes: - Drug reaction - Helminth infection -
CD3-CD4+ T cells ... malignancy - Immune ... hypereosinophilia #HE #Differential
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
Immune Reactions ... IL-2 Muromonab-CD3 ... #Pharmacology #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... immunofluorescence Immune ... Goodpasture's) Pauci-immune ... Glomerulonephritis #Vasculitis #differential
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... Others: Cellular immune ... Unknown cause Treatment
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... Syndromes: • Pauci-Immune ... Cryoglobulinemia) • Immune ... Investigations • Labs: CBC ... Renal #Syndrome #differential
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Difficile Infection (CDI ... Perforation) Pathophysiology ... despite appropriate treatment ... Treatment Guideline ... diagnosis #management #treatment
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Artifact (redo CBC ... effect following treatment ... Thrombocytosis #Differential
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Immune Reconstitution ... reconstituted immune ... Leishmaniasis Differential ... #IRIS #Immune ... Inflammatory #Syndrome #Differential
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology Risk factors: - Low CD4 count - Disseminated OI -
Immune Reconstitution ... Syndrome (IRIS) - Pathophysiology ... factors: - Low CD4 ... duration or OI treatment ... Syndrome #IRIS #Pathophysiology
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