9 results
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS)
Absolute Insulin deficit:
 - Type I DM:
Pathophysiology ... of Diabetic Ketoacidosis ... - Type II DM pts ... #comparison #endocrinology ... #ketoacidosis #
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
of Diabetic Ketoacidosis ... primary anabolic hormone ... counterregulatory hormones ... #Diabetic #Ketoacidosis ... #Endocrinology
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus
Calcium - Net Effect Hypercalcemia:
   ↑ intestinal
Parathyroid Hormone ... (PTH) Effect in ... Calcium - Net Effect Hypercalcemia ... Calcium #Phosphorus #pathophysiology ... #endocrinology
DKA vs HHS
 - Think of DKA and HHS on a spectrum of hyperglycemic emergencies
 -
of DKA and HHS ... sensitive - if pts ... laboratory #diagnosis #endocrinology ... #comparison #diabetic ... #ketoacidosis #
Hyperglycemic Crisis - Algorithm for DKA/HHS

Diagnostic criteria for DKA:
 • pH < 7.3
 • Anion gap
Algorithm for DKA/HHS ... : • pH > 7.3 ... Algorithm #management #endocrinology ... #Diabetes #DM2 ... #Ketoacidosis
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic ... Ketoacidosis (EuDKA ... acidosis with pH ... level < 200 mg/dL Pathophysiology ... diagnosis #management #endocrinology
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
IVF or PO): The pt ... • Alcoholic ketoacidosis ... • Diabetic ketoacidosis ... of both DKA & HHS ... diagnosis #management #endocrinology
Hypercalcemia - Hormones and Pathophysiology  
Calcitriol:
 • Bones: Enhances mineralization
 • GI Tract: ↑ Ca2+
Hypercalcemia - ... Hormones and Pathophysiology ... Ca2+, ↑ PO4- PTH ... #Hormones #Pathophysiology ... #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... To prevent hypokalemia ... ensure patient has ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology