9 results
diagnosis hematology differential causes pt aptt prolonged anticoagulant anticoagulation apixaban arterial bandemia biliary bleeding bruising cascade cbc chemistry cholangitis cirrhosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... dysfunction (25%) • Hepatic ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... Jcortesizaguirr #Abnormal ... #differential #hematology ... #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology ... Rivaroxaban #Edoxaban #heparin
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... amyloidosis #Abnormal ... #differential #hematology ... #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... Acquired: • Heparin ... PT/ABNORMAL PTT ... intravascular coagulation ... Differential #Diagnosis #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
cardiac valves (septic ... Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... Venous #Arterial #pathophysiology ... #hematology #differential
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
• Abnormal temperature ... bacteremia • Abnormal ... hypotension or septic ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... • ALT & AST normal ... • Bilirubin - Normal ... malignancies, Hepatic ... diagnosis #workup #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... • Albumin • Coagulation ... replaced by non-hepatic ... of ALP • Near normal ... #differential #Hepatology
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