38 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology ... #comparison
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... #DrugInduced #Liver ... #Injury #Pathophysiology ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... Hemochromatosis, Wilson's disease ... antitrypsin • Other: NAFLD ... HELLP, Celiac disease ... #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... Antitrypsin • Other: NAFLD ... Syndrome, Celiac Disease ... #Injury #Differential ... Acute #algorithm #hepatology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
disease algorithm ... or liver disease ... disease; NFS, NAFLD ... NonAlcoholic #FattyLiver #Disease ... Referral #Management #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... 100-500): • NAFLD ... (Drug-induced liver ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
of Severe Acute Liver ... Injury - Ichemic ... injury - Viral ... hepatitis - Wilson disease ... #Differential #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD ... • Cholestatic disease ... Others #LFTs #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Venoocclusive disease ... Hereditary: Wilson Disease ... disease: > 2 ... diagnosis #algorithm #hepatology
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
and Bleeding in Liver ... Disease Increased ... Clot #Cirrhosis #Pathophysiology ... #Hepatology #Liver