36 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Hemochromatosis - Nonalcoholic ... fatty liver disease ... - Wilson disease ... Venoocclusive disease ... #Differential #Hepatology
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Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Venoocclusive disease ... Hereditary: Wilson Disease ... Autoimmune hepatitis, PBC ... disease: > 2 ... diagnosis #algorithm #hepatology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Folate deficiency, Liver ... Abetalipoproteinemia, Liver ... Artifact, Uremia, Liver ... stomatocytosis, Liver ... differential #diagnosis #hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... Highest • Bone • Liver ... biliary Cholangitis (PBC ... - PSC - Other ... Diagnosis #Algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Syndrome, Celiac Disease ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... , Infiltrative Disease ... Acute #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... cholestasis → Cirrhosis/Liver ... but elevated as disease ... or higher • Liver ... diagnosis #workup #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
female-predominant disease ... of autoimmune disease ... relative with PBC ... Cholestasis #PBC ... #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
associated autoimmune disease ... of autoimmune disease ... Liver biopsy findings ... #PBC #Primary ... Diagnosis #Algorithm #hepatology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
disease algorithm ... disease of unknown ... #NonAlcoholic #FattyLiver ... #Disease #NAFLD ... Referral #Management #Hepatology