64 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Venoocclusive disease ... Hereditary: Wilson Disease ... of cholestatic disease ... disease: > 2 ... diagnosis #algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Ducts - PBC ... , PSC, Alcoholic ... Biliary stricture, PSC ... Algorithm #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... Highest • Bone • Liver ... biliary Cholangitis (PBC ... - PSC - Other ... Diagnosis #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
of cholestatic disease ... disease: > 2 ... • Bilirubin: RBC ... • LDH: Heart, RBC ... #differential #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... cholestasis → Cirrhosis/Liver ... obstruction • ALP ... or higher • Liver ... diagnosis #workup #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
associated autoimmune disease ... of autoimmune disease ... Elevated ALP 2. ... Liver biopsy findings ... Diagnosis #Algorithm #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Hemochromatosis - Nonalcoholic ... fatty liver disease ... - Wilson disease ... Venoocclusive disease ... #Differential #Hepatology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Folate deficiency, Liver ... Abetalipoproteinemia, Liver ... Artifact, Uremia, Liver ... stomatocytosis, Liver ... differential #diagnosis #hematology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Syndrome, Celiac Disease ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... , Infiltrative Disease ... Acute #algorithm #hepatology