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diagnosis management differential algorithm hbv hepatitisb lfts transaminitis indications syndrome aclf acute aih albumin ascites autoimmune biliary causes chemistry cholangitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Injury (DILI) ... Viral Hepatitis ... #Cirrhosis #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... • Chronic Viral ... Hepatitis Moderate ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Nonalcoholic fatty liver ... heart failure (chronic ... #Differential #Hepatology
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 Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
Differential Diagnosis Chronic ... liver disease ( ... cirrhosis or chronic ... hepatitis) - 80% ... Differential #Diagnosis #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... viremia or have cirrhosis ... Chronic Hepatitis ... Diagnosis #Management #Treatment ... #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... e.g. ascites), Chronic ... hepatitis fibrosis ... • Autoimmune hepatitis ... #Algorithm #hepatology
Indications for Albumin for Management of Cirrhosis • Large volume paracentesis (>5 liter) - 8g per
Management of Cirrhosis ... ) - 8g per liter ... • Acute kidney injury ... Indications #Management #Cirrhosis ... #treatment #hepatology
Hepatitis B Disease Progression Timeline • > 90% of infected children progress to chronic disease (<5%
Hepatitis B Disease ... individuals develop Liver ... of developing cirrhosis ... #HepatitisB #Disease ... Timeline #Prognosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... : < 1 • Cirrhosis ... : > 3 • Chronic ... #injury #hepatitis ... diagnosis #algorithm #hepatology
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