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diagnosis differential causes acute anticoagulant anticoagulation apixaban arterial biliary cascade chemistry cholangitis cirrhosis clot congenital dabigatran dic dili disseminated druginduced
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Bilirubin - ... week • Direct bilirubin ... • Albumin • Coagulation ... replaced by non-hepatic ... #differential #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Vasculature • Hepatic ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... disease, Hepatic ... presentation: Hepatic ... #Algorithm #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... dysfunction (25%) • Hepatic ... DIC • Severe Liver ... 100mg/dL) - Heparin ... treatment #management #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... at the site of injury ... diagnosis #models #hematology ... #pathophysiology ... Rivaroxaban #Edoxaban #heparin
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
of hemolysis or liver ... injury ... associated with bilirubin ... • Defect in hepatic ... #hepatology #diagnosis
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... intravascular coagulation ... Vasculitis • Injury ... Venous #Arterial #pathophysiology ... #hematology #differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... slightly elevated • Bilirubin ... or higher • Liver ... malignancies, Hepatic ... diagnosis #workup #hepatology
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