46 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... #Bilirubin #Metabolism ... #Pathophysiology ... #hepatology #Liver
Functions of the Liver

Storage 
Degradation 
Metabolism 
Synthesis 

#Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Synthesis #Pathophysiology ... #Functions #Liver ... #Hepatology #Synthesis ... #Storage #Metabolism
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... NASH, Genetic / Metabolic ... AST:ALT > 2.5 - Alcoholic ... #Patterns #Liver ... #Injury #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... - NAFLD, Alcohol ... - PBC, PSC, Alcoholic ... LFTs #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... #Pregnancy #hepatology ... #pathophysiology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
or 60 (male) g alcohol ... within 7 days) or metabolic ... liver disease ( ... Possible drug-induced liver ... Hepatitis #AH #hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... The presence of metabolic ... aminotransferase; ARLD, alcohol-related ... dehydrogenase; NAFLD, non-alcoholic ... #Algorithm #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • NAFLD • Alcohol ... disease US — Normal ... Ducts • PSC • Alcoholic ... Others #LFTs #Hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
and Bilirubin Metabolism ... insult Bilirubin metabolism ... Tests #Laboratory #Metabolism ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
metabolic energy ... fatty acid (FA) metabolism ... seen in chronic alcoholics ... Treat concomitant alcohol ... differential #diagnosis #management