30 results
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... ) Pathophysiology ... free fatty acid metabolism ... Pregnancy #hepatology ... #pathophysiology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Wilsons, Pregnancy - AFLP ... - NAFLD, Alcohol ... - PBC, PSC, Alcoholic ... Algorithm #diagnosis #hepatology
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... #Bilirubin #Metabolism ... #Pathophysiology ... #hepatology #Liver
Functions of the Liver

Storage 
Degradation 
Metabolism 
Synthesis 

#Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Synthesis #Pathophysiology ... #Functions #Liver ... #Hepatology #Synthesis ... #Storage #Metabolism
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... • NAFLD • Alcohol ... Ducts • PSC • Alcoholic ... Others #LFTs #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Metabolic/Hereditary ... • AST/ALT > ALP ... disease - If ALP ... ALT Ratios: • Alcoholic ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Identify Acute Liver ... ALT Ratios: • Alcoholic ... liver disease: ... #differential #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
or 60 (male) g alcohol ... within 7 days) or metabolic ... liver disease ( ... Possible drug-induced liver ... Hepatitis #AH #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... NASH, Genetic / Metabolic ... AST:ALT > 2.5 - Alcoholic ... #Patterns #Liver ... #Injury #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
and Bilirubin Metabolism ... insult Bilirubin metabolism ... Tests #Laboratory #Metabolism ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology