46 results
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Alkalosis - Differential ... , Gitelman Syndrome ... hyperaldosteronism • High PRA: Renal ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Alkalosis - Differential ... , Gitelman Syndrome ... hyperaldosteronism • High PRA: Renal ... Diagnosis #Algorithm #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... → Hypokalemia Metabolic ... alkalosis - ... #Syndrome #Pathophysiology
Causes of Metabolic Alkalosis - Differential Diagnosis
Chloride depletion syndromes
 • Gastrointestinal losses
    -
Causes of Metabolic ... Alkalosis - Differential ... villous adenomas • Renal ... - Gitelman ... <2 mmol/L) #Metabolic
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Algorithm Extra-renal ... Low intake • Metabolic ... loss (Diarrhea) Renal ... , Gitelman syndrom ... potassium #low #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal ... , Renal tubular ... #nephrology #management ... #pathophysiology
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... alkalosis ... alkalosis ... diuretic use, Bartter syndrome ... , Gitelman syndrome
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... diuretics after renal ... generally indicates a renal ... furosemide-like lesion) • Gitelman ... Diagnosis #Causes #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
alkalosis - Fistulas ... - Diarrhea • RENAL ... - Bartter - Gitelman ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride