669 results
Lactic Acidosis - Differential Diagnosis Framework

Type A: Impaired O2 Delivery (DO2)
 • Decreased O2 Delivery: Hypotension
Lactic Acidosis ... Beta-Agonists, ↑ work ... DKA, Alcoholic lactic ... with negative lactate ... @nickmmark #Lactic
Modified penicillin binding proteins as mechanism of resistance to antibiotics.
Penicillin Binding Proteins (Transpeptidases) cross link peptidoglycan
cell wall - Beta-lactam ... remains active as it works
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type B Type A Lactic ... Cardiogenic shock Type B Lactic ... Short bowel (D-lactate ... transcriptases, Linezolid #Lactic
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
Lactic Acidosis ... Pathophysiology Lactic ... Lactate is the conjugate ... base of lactic ... as an arterial lactate
Lactic acid was first found & described in sour milk by Karl Wilhelm Scheele in 1780.
Lactic acid was ... occurrence of lactic ... Lactic acid is essentially ... equilibrium with lactate ... Thus, lactate is
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
hormones that work ... But we also have Lactic ... convert Pyruvate to Lactate
Lactic Acidosis - Classification and Differential Diagnosis
Type A Lactic Acidosis: Inadequate Oxygen Delivery
 • Anaerobic muscular
Lactic Acidosis ... Diagnosis Type A Lactic ... Anemia Type B Lactic ... Fructose, Isoniazid, Lactate-based ... #TypeA #TypeB #lactate
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... contribute to lactic ... Elevation Type A Lactic ... Methemoglobinemia Type B Lactic ... #Lactic #Acidosis
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
acetaminophen use L-lactate ... metabolism D-lactate ... toxicity causes lactic
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Lactated Ringers ... mEq/L • Sodium lactate ... pH of 4-7.5 Lactated ... mEq • Sodium Lactate ... NOT lactic acid