1015 results
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
Lactic Acidosis ... - Overview and Pathophysiology ... Lactate is the conjugate ... as an arterial lactate ... differential #diagnosis #pathophysiology
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Metformin Associated Lactic ... Acidosis (MALA) Pathophysiology ... recycles peripheral lactate ... production  increased lactate
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
increased pyruvate and lactate ... Increased pyruvate & lactate ... also seen • Lactic ... - Increased Lactate ... beriberi #nutrition #pathophysiology
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type B Type A Lactic ... Cardiogenic shock Type B Lactic ... Short bowel (D-lactate ... transcriptases, Linezolid #Lactic
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Lactulose → ↑ Lactic ... Acid, Acetic Acid ... ammonia #hepatology #pathophysiology
Lactic acid was first found & described in sour milk by Karl Wilhelm Scheele in 1780.
Lactic acid was ... occurrence of lactic ... Lactic acid is essentially ... equilibrium with lactate ... Thus, lactate is
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Lactated Ringers ... mEq/L • Sodium lactate ... pH of 4-7.5 Lactated ... mEq • Sodium Lactate ... NOT lactic acid
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... contribute to lactic ... Elevation Type A Lactic ... Methemoglobinemia Type B Lactic ... #Lactic #Acidosis
Lactic Acidosis - Classification and Differential Diagnosis
Type A Lactic Acidosis: Inadequate Oxygen Delivery
 • Anaerobic muscular
Lactic Acidosis ... Diagnosis Type A Lactic ... Anemia Type B Lactic ... Fructose, Isoniazid, Lactate-based ... #TypeA #TypeB #lactate
Lactic Acidosis - Differential Diagnosis Framework

Type A: Impaired O2 Delivery (DO2)
 • Decreased O2 Delivery: Hypotension
Lactic Acidosis ... DKA, Alcoholic lactic ... with negative lactate ... sugars into D-Lactate ... @nickmmark #Lactic