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diagnosis management coccidioidomycosis differential echinocandins pharmacology workup anidulafungin antibiogram antibiotics aspergillus associated bcnie betadglucan biomarkers bloodculture capd caspofungin coccidioides comparison
Antifungal Coverage Activity Antibiogram Spectrum of action of systemic antifungal agents. Solid blocks represent species in
Antifungal Coverage ... action of systemic antifungal ... microbiological and clinical ... lines indicate fungal ... #Pharmacology #InfectiousDiseases
Ever had a #traveler come in to your clinic with #fever and you were not sure
come in to your clinic ... with #fever and ... incubation period and geography ... diagnosis #medicine #infectiousdisease ... #fever #traveler
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
Fever of Unknown ... Refer to your ‘Fever ... the respective fungal ... pathogens based on geography ... node biopsy • Clinical
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... glucan synthesis in fungal ... usually works clinically ... salvage therapy, never ... Echinocandins #Antifungal
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... component of many fungi ... cut-offs defined in clinical ... of mold-active antifungals ... post-2010 almost never
CAPD-associated peritonitis (Continuous Ambulatory Peritoneal Dialysis) - 5 Things To Know Diagnosis (Two of the following): (1) Clinical
following): (1) Clinical ... culture Note that fever ... peritonitis • Fungal ... prior abx use, fungal ... Diagnosis #Management #InfectiousDiseases
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
fastidious bacteria or fungi ... antimicrobials, clinical ... will vary with geographic ... Tropheryma whipplei, Fungi ... differential #workup #infectiousdiseases
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... has five major clinical ... stain of clinical ... • Isolated fever ... ) #Mycoses #InfectiousDiseases
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
noncompliance • Clinical ... initiation Clinical ... Fever, chills, lack ... contagiosum virus • Leishmaniasis ... -6 weeks after antifungal
Majocchi’s Granuloma due to Trichophyton rubrum This is GMS stain and culture of a skin biopsy
No fever. ... Histopath shows fungal ... Rx: Oral antifungal ... recommended Mayo Clinic ... Trichophyton #rubrum #clinical
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