79 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... only curative treatment ... #Management #treatment ... #hematology #oncology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
for secondary causes ... glucocorticoid treatment ... organ-specific signs ... #Differential #diagnosis ... #hematology #eosinophilia
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Autoimmune diseases ... Adult-onset Still disease ... Treatment: • ... #management #treatment
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Cardiovascular disease ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... WBC >100k, + lab signs ... Lysis of tumor cells ... Syndrome #TLS #diagnosis ... #management #hematology
Syncope is a sudden, transient loss of consciousness, which is thought to be secondary to cerebral
structural heart disease ... further guide management ... orthostatic vital sign ... the underlying disease ... The treatment strategy
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... and Management ... thrombocythemia), Autoimmune disease ... #Management #treatment ... #hematology #differential
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
and Management ... screening for disease ... normal in mild cases ... #Management #treatment ... #hematology
Hashitoxicosis

‘Leakage’ symptoms of active Hashimoto’s disease

- Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in
active Hashimoto’s disease ... thyroiditis that causes ... lymphocytes and plasma cells ... Hashitoxicosis #Hashimotos #Endocrinology ... #Diagnosis #Pathophysiology
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
and Management ... present, symptoms, signs ... von Willebrand disease ... #Management #Summary ... #treatment #hematology