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diagnosis differential emergencies hematology management oncologic tls tumor bone bony cancer hemeonc hypokalemia leukemia leukostasis low orthopedics potassium primary sarcoidosis
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... neutrophil count < 500 cells ... Superior Vena Cava Syndrome ... EMERGENCIES: Tumor Lysis ... Syndrome: • Azotemia
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... Burkitt, SCLC Cells ... #Syndrome #TLS ... #oncology
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... - Refeeding Syndrome ... #causes #potassium ... #low #pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Syndrome Leukostasis ... : • Pathophysiology ... high WBC count cause ... Syndrome: • Pathophysiology ... cells releasing
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
Differential Diagnosis Algorithm ... Tumors #Tumours #MSK ... Differential #Diagnosis #Algorithm ... #Orthopedics #Causes ... #Oncology #Radiology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... tissue: Epithelioid cells ... symptoms are not caused ... anterior/posterior MSK ... • Heerfordt syndrome
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... & DIC • Tumor lysis ... syndrome: Develops ... Leukemia #Hematology #Oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... TLS (tumor-lysis ... Treat underlying cause ... interventional radiology ... “big & sticky” cells
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