13 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... high WBC count cause ... Syndrome: • Pathophysiology ... cells releasing ... unless worrisome EKG
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Hyperviscosity Syndrome ... neutrophil count < 500 cells ... Superior Vena Cava Syndrome ... EMERGENCIES: Tumor Lysis ... Syndrome: • Azotemia
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... Burkitt, SCLC Cells ... #Syndrome #TLS ... #oncology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... with Ca only if EKG ... Walid Malki, MD, MS ... #Syndrome #TLS ... #oncology #management
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the heart that
Wolff–Parkinson–White syndrome ... WPW is caused by ... #Pathophysiology ... #Diagnosis #Cardiology ... #MedStudent #EKG
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Refeeding Syndrome ... Low BMI < 18.5 kg ... PO4 and Mg into cells ... Constipation - MSK ... #diagnosis #pathophysiology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... tissue: Epithelioid cells ... symptoms are not caused ... of diagnosis (e.g ... anterior/posterior MSK
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Release from blast cells ... Prednisone 5mg/kg ... management #hematology #oncology
Approach to ECGs - Tachy/Bradyarrhythmias
Tachyarrhythmias - HR > 100
Wide
  (1) VT - DANGER
  (2)
(2) Sick Sinus Syndrome ... 200ms from longer pause ... block (lower AV cells ... #EKG #diagnosis ... electrocardiogram #cardiology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... & DIC • Tumor lysis ... syndrome: Develops ... Leukemia #Hematology #Oncology