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diagnosis emergencies hematology management oncologic acutekidneyinjury cairoandbishop cancer differential etiology hemeonc howardcriteria hyperkalemia hyperphosphatemia hyperuricemia hypocalcemia leukemia leukostasis presentation prognosis
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... #Lysis #Syndrome ... #TLS #Pathophysiology ... #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... high WBC count cause ... Lysis Syndrome: ... : Lysis of tumor ... #Lysis #Syndrome
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... of neoplastic cells ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... Walid Malki, MD, MS ... wandering_er #Tumor ... #Lysis #Syndrome ... #TLS #oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... neutrophil count < 500 cells ... Superior Vena Cava Syndrome ... EMERGENCIES: Tumor ... Lysis Syndrome:
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... (tumor-lysis syndrome ... low Ca - q8 h TLS ... Treat underlying cause ... interventional radiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... Fibrinolysis & DIC • Tumor ... lysis syndrome: ... Leukemia #Hematology #Oncology
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