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diagnosis hematology oncology management symptoms hemeonc lymphocytic mds myelodysplastic avascularnecrosis features hemophagocytic hlh lymphohistiocytosis myelodysplasia sarcoidosis sicklecell syndrome syndromes workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... (Chronic Myeloid ... -> AML: Blast crises ... - infiltrates (anemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Physical Exam/Signs ... • Neutropenia, anemia ... microglobulin Treatment ... #Chronic #Lymphocytic
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Crisis Sickle-cell ... Crises can be precipitated ... The underlying pathophysiology ... of the baseline anaemia ... #Features #Signs
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... #hematology #hemeonc
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Leukemia • Idiopathic
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... tissue: Epithelioid cells ... symptoms are not caused ... skin (16-32%): lupus ... Diagnosis #Management #Signs
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
) - Sickle-cell ... disease (sickle crisis ... ) • Multiple causes ... therapy - Lupus ... AvascularNecrosis #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Presentation • Common Signs ... - Cytopenias (anemia ... Pathophysiology ... Diagnosis #Management #Hematology
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