12 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... apical membrane of cells ... tubule (DCT) Clinical ... ratio 0.5%) Differential ... Rhabdomyolysis Treatment
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... ↑ Aldosterone: Kidney ... , Gitelman syndrome ... urine #potassium #differential ... algorithm #diagnosis #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... differentiating kidney ... , Gitelman syndrome ... diagnosis #Algorithm #differential ... #potassium #nephrology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
- Differential ... of breath • Neurologic ... neutrophil count < 500 cells ... renal failure • Hypocalcemia ... #differential #
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... malignancies Treatment ... #AKI #Cancer #Oncology ... #Differential # ... Classification #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects in Kidney ... Tubule Epithelial Cells ... ascending limb Gitelman ... #Nephrology #Diagnosis ... #Differential #
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... diuretic use), Gitelman's ... syndrome (mimics ... #Causes #differential ... #diagnosis #nephrology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Blood Work: - Hypokalemia ... excretion of Cl > 0.5% Clinical ... #Syndrome #Diagnosis ... #Workup #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Dermatomyositis Clinical ... nephrotoxicity to kidney ... tubular cells ... #nephrology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup and Differential ... heart failure, neurologic ... disturbance, or acute kidney ... 109 mm Hg) with clinical ... Neurologic disorders