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diagnosis rheumatology dermatology differential autoimmune clinical sign antimda5 antimda5dm antinxp2 antinxp2dm comparison disorders eosinophil eosinophilia gottronspapules heliotrope inflammatory management myopathies
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Dermatomyositis ... heliotrope rash, Shaw ... sign, holster sign ... #diagnosis #rheumatology
Shawl sign poikiloderma in Dermatomyositis Poikiloderma in general is a common finding in older individuals with chronic
Shawl sign poikiloderma ... RashDecisionz #Shawl ... #sign #poikiloderma ... #Dermatology #Clinical ... #Photo #Neck
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies Dermatomyositis ... periorbital heliotrope, shawl ... sign Polymyositis ... Necrotizing Autoimmune Myositis ... Inclusion Body Myositis
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl ... sign) • Violaceous ... Inverse Gottron’s sign ... ulcerations • Skin
Dermatomyositis with heliotrope rash, shawl sign, and Gottron's papules A middle-aged man describes progressive difficulty combing his
Dermatomyositis ... heliotrope rash, shawl ... sign, and Gottron's ... #dermatology #clinical ... #photo
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... organ-specific signs ... symptoms (eg, skin ... Eosinophil #Disorders #Algorithm ... Differential #diagnosis #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... chest (in a V-sign ... shoulders (in a shawl ... sign) • Violaceous ... ulcerations • Skin
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... ) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... #Myopathy #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... purpura: Strong sign ... Multinucleated giant cells ... Conjunctivitis, mucositis ... Differential #Diagnosis #Rheumatology
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