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diagnosis differential leukemia management algorithm anemia chronic classification lymphoma analysis blood causes clinical comparison diffuse disorders hemeonc hemolytic interpretation lad
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can infiltrate ... • Peripheral smear ... : Smudge cells or ... basket cells can ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
lymphadenopathy • Blast cells ... Rapidly rising blast cells ... : Granulocytic cells ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
typically of B-cell ... type (B cell, T ... cells, natural ... killer (NK) cells ... #differential #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Biopsy • Non-Hodgkin's ... Reed-Sternberg Cells ... Biopsy • Hodgkin's ... Algorithm #Causes #Hematology ... #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... , smudge cells are ... Transformation to large cell ... uw_IMresidency #CLL ... #hematology #hemeonc
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
anemia Sickled red cells ... : Sickle cell disease ... Bite cells: G6PD ... #Analysis #hematology ... #microscopy #interpretation
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... cells. ... Workup: • Full ... classification #hematology ... #oncology #management
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- 5% RS cells absent ... (LP) tumour B cells ... common - T Cell ... ~10% - B-Cell ... pathophysiology #Hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
non-specific red cell ... polychromatophilic cells ... hemolytic #anemia #Hematology ... #Pathology #Smear ... #Microscopy
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Peripheral Smear ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
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