29 results
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... abnormal under a microscope ... Peripheral blood smear ... Syndromes #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... • Peripheral smear ... Phosphorus CLL ... #Leukemia #Hematology ... #Oncology #Diagnosis
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... : Sickle cell disease ... Peripheral #Blood #Smear ... #Analysis #hematology ... #microscopy #interpretation
Sickle cell anemia and Howell Jolly bodies (nuclear remnants).

 - Dr. Abubaker Elshaikh
@ElshaikhMD

#SickleCell #HowellJolly #Body #Bodies
Sickle cell anemia ... Bodies #Pathology #Hematology ... #Smear #Clinical ... #Microscopy
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
• Lymphoid (ALL ... Disorders - Myelodysplastic ... • Lymphoid (CLL ... or λ), Smudge Cells ... Blood #Disorders #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... = funny-shaped cells ... Allogeneic stem cell ... Management #treatment #hematology ... #oncology
A non-subtle example of true Sezary syndrome.  Patient presented with erythroderma without antecedent history of
Sezary #Syndrome #Cells ... Clinical #Pathology #Smear ... #Microscopy #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
• Peripheral smear ... : Smudge cells or ... basket cells can ... diagnosis #workup #oncology ... #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
non-specific red cell ... polychromatophilic cells ... hemolytic #anemia #Hematology ... #Pathology #Smear ... #Microscopy
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... multiple myeloma, myelodysplastic ... criteria for 1) hematologic ... multiple myeloma or myelodysplastic ... (12%) • giant cell