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diagnosis clinical leukemia cll hemeonc lymphocytic pathology acanthocytes amyloid amyloidosis anemia blood cells differential emergencies interpretation management mcleod mds myelodysplasia
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood Smear ... Analysis Hypochromia ... Peripheral #Blood #Smear ... #Analysis #hematology ... #microscopy #interpretation
A non-subtle example of true Sezary syndrome. Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... #Cells #Clinical ... #Pathology #Smear ... #Microscopy #Hematology
Beautiful acanthocytes/spur cells in a patient with McLeod Syndrome. X-linked disorder characterized by reduced expression of
acanthocytes/spur cells ... patient with McLeod Syndrome ... associated with chronic ... #Smear #Pathology ... #Microscopy #Clinical
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... Marrow Failure • Chronic ... appear normal, but analysis ... #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... • Peripheral smear ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Peripheral smear ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... • Peripheral smear ... lymphocytes, smudge cells ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
amyloidosis • Dialysis-related ... : • Nephrotic syndrome ... Carpal tunnel syndrome ... Increased plasma cells ... polarized light microscopy
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... ): - Hematologic ... “big & sticky” cells ... denosumab, steroids, dialysis ... #Emergencies #Oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Multinucleated giant cells ... (PR3-ANCA)): Microscopic ... Eosinophilia, asthma, chronic ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
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