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diagnosis hematology oncology leukemia hemeonc lymphocytic mds myelodysplastic common cvid hemophagocytic hlh hypogammaglobulinemia immunodeficiency immunology lymphohistiocytosis myelodysplasia syndromes treatment variable
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... weeks without infection ... • Neutropenia, anemia ... • Richter’s Syndrome ... #Chronic #Lymphocytic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... petechiae) • Frequent infections ... • Aplastic Anemia ... Marrow Failure • Chronic ... • Parvovirus infection
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... Allogeneic stem cell
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... 5) Symptoms of anemia ... Complications: 1) Infection ... hemeonc #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... Autoimmunity • Chronic ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... syndrome, HIV)
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... with the HLH syndrome ... Triggers: ▪ Infections ... - Cytopenias (anemia ... underlying trigger: Infections
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