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diagnosis hematology differential management oncology causes algorithm vasculitis classification leukemia activetb cll latenttb lymphocytic tb treatment tuberculosis workup allergy anemia
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Avg age of DX ... Autoimmunity • Chronic ... DDX - Other causes ... Malignancies • Chronic ... hypogammaglobulinemia #immunology #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Pseudotumor - Infectious ... History of Bleeding, Infection ... Age > 50 • Chronic ... Reed-Sternberg Cells ... Algorithm #Causes #Hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Diagnosis Algorithm Infection ... Myeloproliferative Disorder • Chronic ... pancytopenia, blast cells ... Algorithm #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... weeks without infection ... Scoring system: DDX ... Contamination, colitis DDX ... leukemia #CLL #Chronic
Important organisms in Chronic Granulomatous Disease (CGD): - Staph aureus - Serratia marcescens - Burkholderia cepacia
Important organisms in Chronic ... febrilepodcast.com] #CGD #Chronic ... Granulomatous #Disease #infections ... #differential #ddx ... #diagnosis #microbiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... bruising, bleeding, infection ... plaques) AML Dx ... #Leukemia #Hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
similarly to mast cells ... Disorders: • Chronic ... Diabetes/DKA Infections ... : • helminth infections ... Diagnosis #causes #hematology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
granulomatosis - microscopic ... malignomas, and infectious ... syndrome induced by chronic ... Vessels #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: HCV infection, ... HBV infection, ... DDX: • ANCA (Antineutrophil ... vasculitis - GPA, EGPA, microscopic ... classification #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
petechiae) • Frequent infections ... Macrocytic anemia DDX ... Marrow Failure • Chronic ... • Parvovirus infection ... Syndromes #diagnosis #hematology
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