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diagnosis hematology leukemia chronic lymphocytic agglutinin amyloid amyloidosis anemia apml cancer cold differentiation disease emergencies hemeonc hemolytic mds myelodysplasia myelodysplastic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... develop leukostasis syndrome ... smear: Blasts ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... smear: Smudge cells ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... Smear: • Dysplastic ... blood count with differential ... smear • Bone marrow ... diagnosis #hematology #oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential ... Neurologic deficits (peripheral ... neutrophil count < 500 cells ... Vomiting, decreased urine ... #differential #
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... Diagnosis: • Peripheral ... smear → small rnature-appearing ... Lymphocytic #Leukemia #oncology ... hemeonc #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... IgM) • Blood smear ... younger pts) Differential ... sensitize red blood cells ... passage of red-brown urine
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... : UA, Urine protein ... sparing of the lung periphery ... #differential # ... diagnosis #management
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
: • Nephrotic syndrome ... dissociation in urine ... Carpal tunnel syndrome ... Increased plasma cells ... polarized light microscopy
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
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