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differential oncology management algorithm causes rheumatology hemolytic leukemia mds myelodysplastic treatment acquired agglutinin aplastic arteritis ascites atlas autoinflammatory b12 chronic
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
transfusion • Target cells ... • Sickle cells ... alcoholism • Burr cells ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... RBCs - Sickle Cells ... , Target Cells ... Inflammation • Cancer ... Algorithm #Causes #Hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... hematopoietic stem cells ... blood myeloid cells ... NEJM Review: https
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood cells ... abnormal under the microscope ... abnormal under a microscope ... abnormal under the microscope ... #diagnosis #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
and laboratory diagnosis ... non-specific red cell ... polychromatophilic cells ... #Hematology #Pathology ... #Smear #Microscopy
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... Allogeneic stem cell ... Management #treatment #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
hematopoietic stem cells ... number of CD34+ cells ... cellularity + dysplastic cells ... number of CD34+ cells ... Number of CD34+ cells
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... Skin: - CLL cells ... smear: Smudge cells ... or basket cells ... • Neutropenia, anemia
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... - Diagnosis and ... adsorption onto cancer ... cells (and subsequent ... #treatment #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
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