59 results
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
Dacrocytes (tear drop cells ... each of the above photos ... metaplasia, pernicious anemia ... some hemolytic anemias ... Path #BloodSmear #Blood
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
..A peripheral-blood ... Spur cells acquire ... resolve despite blood ... #NEJM #clinical ... #peripheral #blood
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... a more generic term ... In the right photo ... seen in hemolytic anemias ... Path #BloodSmear #Blood
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
A peripheral-blood ... revealed 25% plasma cells ... Clinical #HONC #Derm ... Leukemia #Smear #NEJM
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Megaloblastic Anemia ... Sickled red cells ... disease Bite cells ... #Peripheral #Blood
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
) - Two target cells ... seen in the left photo ... present in the left photo ... with hemolytic anemias ... Path #BloodSmear #Blood
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... transfusion • Target cells ... Hemoglobinopathies • Teardrop cells ... • Sickle cells ... alcoholism • Burr cells
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... • Peripheral blood ... History • Bite cells ... Deficiency • Sickle cells ... → Sickle Cell anemia
Sickle cells
These photos show sickle cells on peripheral blood smears. In the left photo target cells
photos show sickle ... blood smears. ... In the left photo ... no significant anemia ... Path #BloodSmear #Blood
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
• stored red blood ... cells - Hb variant ... • chronic anæmia ... - Sickle cell anemia