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management oncology clinical dermatology differential rheumatology acquired amyotrophic cell comparison cutaneous emergencies gammopathy gangrenosum hemeonc larva lateral mds mgus migrans
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... osteolytic lesions and pathologic ... marrow plasma cells ... if FLC value is also ... #Myeloma #Diagnosis
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... e.g. lymphoma, multiple ... myeloma, Waldenstrom ... #Management #treatment ... #hematology #differential
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
progress to IgM multiple ... myeloma Non-IgM ... progression to multiple ... myeloma, AL amyloidosis ... #diagnosis #oncology
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
appearance known as ... myeloma. ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
amyotrophy with the pathologic ... - Microglial cells ... are the immune cells ... brainstem and multiple ... column Treatment
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... lymphocytes, plasma cells ... the mainstay of treatment ... the setting of multiple ... myeloma or AL amyloidosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
three myeloid hematopoiesis ... factor (GCSF) treatments ... marrow studies Treatment ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Cutaneous larva migrans skin Rash 25 F recent Caribbean vacation, walked barefoot on sand and now with
with creepy rash. diagnosis ... No treatment is ... required unless multiple ... ivermectin is also ... #clinical #photo
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
patients with EMD myeloma ... IFE, FLC assay Pathology ... Bone marrow Treatment ... • Multiple myeloma ... #Workup #Hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... syndrome): - Hematologic ... Leukostasis: - Usually myeloid ... “big & sticky” cells ... Oncology #HemeOnc #Diagnosis
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