5 results
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... associated with Castleman's ... Diffuse plasma cells ... cell disorders (myeloma ... #Diagnosis #Pathology
IgG4-associated conditions

Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
conditions Diagnosis ... really need to see pathology ... positive plasma cells ... Even the pathology ... polyangiitis, and Castleman
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... demineralization) • Renal disease ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia
Clinical
 - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
of autoimmune disease ... morphologic/clinical disease ... but cells are NK ... Lymphocytic #Leukemia #hemepath ... #pathology #diagnosis
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
of multicentric Castleman ... disease, which ... including lymphoma, myeloma ... Histopathological Diagnoses ... agonists #TAFRO #diagnosis