52 results
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... : Sickle cell disease ... Bite cells: G6PD ... #Peripheral #Blood ... hematology #microscopy #interpretation
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... , Liver diseases ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... Morphology #Atlas #key #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myeloproliferative Disease ... cells, red blood ... cells - red blood ... cells, white blood ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
- Differential Diagnosis ... • Peripheral blood ... History • Bite cells ... malignancy, autoimmune disease ... #Differential #Diagnosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
- Differential Diagnosis ... Algorithm Normal Blood ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... • Liver Disease
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... Abnormalities: macrocytic anemia ... including peripheral blood ... myeloid cells ... NEJM Review: https
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Diagnostic Framework ... chronic kidney disease ... , Acute blood loss ... Myelodysplastic syndrome ... #differential #diagnosis
Some of the techniques used for Antenatal Diagnosis

Amniocentesis 
 - Chromosome/micro-array and DNA analysis 
 -
— PCR Fetal blood ... haemoglobin for anaemia ... genetic analysis of cells ... surgery, e.g. laser photo-coagulation ... transfusion syndrome
Ashkenazi Jewish Genetic Screening Algorithm
 • Bloom syndrome
 • Canavan disease
 • Familial dysautonomia
 • Fanconi
Screening Algorithm • Bloom ... syndrome • Canavan ... dysautonomia • Fanconi anemia ... 1A • Joubert syndrome ... Screening #Algorithm #diagnosis
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... In the right photo ... seen in hemolytic anemias ... hemolytic- uremic syndromes ... Path #BloodSmear #Blood