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diagnosis differential hematology clinical algorithm causes smear management bloodsmear path rheumatology dermatology oncology hepatology nephrology peripheral systemic cardiology classification hemolytic
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... , Liver diseases ... Myelodysplastic syndrome ... , Liver diseases ... Hemolytic uremic syndrome
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
• Asplenia Laboratory ... turnover • Acute blood ... • Hemolytic anemia ... End-stage renal disease ... HbA1c #HgbA1c #Laboratory
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Sickled red cells ... : Sickle cell disease ... Bite cells: G6PD ... #Peripheral #Blood
Some of the techniques used for Antenatal Diagnosis Amniocentesis - Chromosome/micro-array and DNA analysis -
haemoglobin for anaemia ... genetic analysis of cells ... surgery, e.g. laser photo-coagulation ... transfusion syndrome ... Testing #Diagnosis #Laboratory
Dacrocytes (tear drop cells) Other poikilocytes resemble a pear or teardrop. The narrow, tapered end may be
Dacrocytes (tear drop cells ... each of the above photos ... metaplasia, pernicious anemia ... some hemolytic anemias ... Path #BloodSmear #Blood
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... Myeloproliferative Disease ... cells, red blood ... cells - red blood ... cells, white blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... Abnormalities: macrocytic anemia ... including peripheral blood ... myeloid cells ... NEJM Review: https
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
..A peripheral-blood ... Spur cells acquire ... resolve despite blood ... #NEJM #clinical ... #peripheral #blood
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... , Drugs, Liver Disease ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... - Peripheral Blood
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... microangiopathic hemolytic anemia ... a clinical and laboratory ... Microangiopathic hemolytic anemia ... polychromatophilic cells
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