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diagnosis differential clinical algorithm oncology dermatology management smear path rheumatology systemic classification generalized hepatology leukemia neurology peripheral pruritus secondary skin
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... , Liver diseases ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... #differential #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... including peripheral blood ... NEJM Review: https
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal Blood ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... by blood cells ... skin that are caused ... Myeloproliferative Disease ... #diagnosis #hematology
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... In the right photo ... hemolytic- uremic syndromes ... Clinical #Path #BloodSmear ... #Blood #Smear #
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
chronic kidney disease ... , Acute blood loss ... Myelodysplastic syndrome ... differential #diagnosis #causes ... #hematology
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
blood smears. ... to sickle cell disease ... no significant anemia ... Clinical #Path #BloodSmear ... #Blood #Smear #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Constitutional Syndromes ... result from low blood ... #oncology #hematology
Spherocytes - The arrow points to one of many spherocytes in this photo. The cells have
spherocytes in this photo ...

Causes of spherocyte ... and hemolytic anemias ... Clinical #Path #BloodSmear ... #Blood #Smear #

Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
DiabetesB12 deficiency, Uremia ... Paraprotein-associated (POEMS syndrome ... Leah Willis via ... differential #diagnosis #causes ... #neurology
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