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diagnosis differential clinical hematology smear oncology algorithm bloodsmear management path dermatology treatment anemia basophils chronic generalized mds myelodysplastic nephrology pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... - Blood and Bone ... -> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
and Plasma-Cell Leukemia ... A peripheral-blood ... revealed 25% plasma cells ... Plasmacytomas #PlasmaCell #Leukemia ... #Smear #NEJM
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Out Secondary Causes ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia
Prolymphocytes In our case, the patient has T-prolymphocytic leukemia (T-PLL) not Acute Myeloid Leukemia (AML). 🔬Tumor
Prolymphocytes In our case ... T-prolymphocytic leukemia ... Acute Myeloid Leukemia ... 🔬Tumor cells are ... Microscopy #Clinical #Blood
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
defined as white blood ... in peripheral blood ... the margins of blood ... Leukemoid reaction ... the underlying cause
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... similarly to mast cells ... Chronic myeloid leukemia ... Chickenpox Other Causes ... Differential #Diagnosis #causes
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Skin: - CLL cells ... or basket cells ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... • Sezary syndrome
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... / Systemic == Blood ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Diagnosis #Algorithm #causes
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... old, ~10,000 new cases ... transformation to acute leukemia ... Myelodysplastic #Syndrome
Schistocytes can assume a shape resembling natural or man-made objects such as arrowheads, fish, collar buttons,
In this case, arrows ... point to helmet cells ... seen in the left photo ... In the right photo ... Path #BloodSmear #Blood
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