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diagnosis hematology oncology syndromes treatment anemia aplastic asplenia bloodsmear clinical coagulation dic differential disseminated howell howelljollybody intravascular jolly mds myelodysplasia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... -> AML: Blast crises ... Pruritis after hot bath ... develop leukostasis syndrome ... • Tumor lysis syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... bone marrow and peripheral ... skin that are caused ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... virus (EBV) • Leukemia ... anemia) Labs: • Peripheral ... result from low blood ... hematology #diagnosis #management
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
Wright-stained peripheral ... blood smears the ... in the right photo ... thalassemia, and leukemia ... #Clinical #Path
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... D-Dimer: ↑ • Peripheral ... Treat primary cause ... #treatment #management
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Goodpasture's cause ... sparing of the lung periphery ... reveals increasing blood ... proteinuria • Path ... differential #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Hypocomplementemia • Can cause ... neuropathy • Peripheral ... Pulmonary amyloidosis, PAH ... Rheumatology #Diagnosis #Management
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