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diagnosis hematology causes classification differentiation disorders edema leukemia lymphomas lymphoproliferative management mds myelodysplasia myelodysplastic ncpe noncardiogenic nonhodgkin pulmonary syndrome syndromes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... rapid onset of symptoms ... Symptoms: • Malaise ... Transformation: • Complication ... Leukemia #Hematology #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... Release from blast cells ... Diagnosis: >3 symptoms ... initiation • Differential ... management #hematology #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Diagnosis Algorithm ... pattern of spread, B symptoms ... not as common ... Classification #pathophysiology ... #algorithm
Uncommon Causes of Noncardiogenic Pulmonary Edema (NCPE) - Differential Diagnosis Framework High Altitude Pulmonary Edema: • Accumulation
Edema (NCPE) - Differential ... some red blood cells ... radiography, pink frothy airway ... pressure due to airway ... edema #causes #differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Antibiotics such as ... blood count with differential ... progression to AML ... diagnosis #hematology #oncology
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