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differential hematology disorders approach arthritis leukemia oncology pain avascularnecrosis chronic classification cll eosinophil eosinophilia fungal infections infectiousdiseases lymphocytic lymphomas lymphoproliferative
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... tumor • Non-bloody ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... • Peripheral blood ... evaluation or workup ... /µL Workup • Screen ... #Differential #diagnosis
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
or nerve root Symptoms ... Arthritis: • Acute ... #Pain #MSK #rheumatology ... #approach #workup ... #differential #diagnosis
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Algorithm Acute ... or λ), Smudge Cells ... Amy Chung, MD, MSc ... #Algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Algorithm Hodgkin ... pattern of spread, B symptoms ... Treated Like Acute ... Classification #pathophysiology ... #Hematology #Diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... the peripheral blood ... bone pain, fever, joint ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Lymphocytosis: Absolute blood ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
• Rheumatologic ... • Major blood ... muscle aches, joint ... Aspergillosis Pathophysiology ... have positive blood
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
affected) - Acute ... bone pain - Joint ... AvascularNecrosis #pathophysiology ... #diagnosis #signs ... #symptoms
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